ARRIGE is now open to members: please join us!

Kick-off meeting for launching the Association for Responsible Research and Innovation in Genome Editing (ARRIGE). Hémicycle Simone Veil, Conseil scientifique régional (CSR), Région Île de France, Paris, 22-23 March 2018.

Dear colleagues,

On behalf of the founding Board of the Association for Responsible Research and Innovation in Genome Editing (ARRIGE),  I am most happy to announce the launching of the ARRIGE membership registration. From today, April 1st, 2019, roughly one year after we held the ARRIGE kick-off meeting in Paris, we will be gladly accepting your requests to formally become a member of ARRIGE.

How to become a member of ARRIGE?

Registration Forms – They can be filed through the ARRIGE web site

Payment – After you fill your Registration Form (Step 1), you can pay your annual membership (in euros) (Step 2), via Paypal (using the form or directly with ARRIGE PayPal account at treasurer@arrige.org) or from your bank app by bank transfer (in such case please send an email to treasurer@arrige.org to be provided with bank details). Payment information can be found in this web site.

Why do we need ARRIGE?

  • Because ARRIGE is the most international of all existing initiatives discussing the responsible use research and innovation of genome editing techniques around the world. In Paris we already gathered delegates from 42 countries, including African, South American and Asian delegates.
  • Because we need to address the various and multidisciplinary issues related to or impacted by genome editing, not only focusing on human embryos. With ARRIGE, we extend the discussions to gene drives, intellectual property issues, GMO vs non-GMO, safety and security issues, biotechnological applications for agriculture and livestock, safe and efficient innovative gene therapies for patients, therapies vs enhancement, ethics issues, laws and regulations, etc…
  • Because there is no satisfactory platform engaging all kinds of public – public engagement platform – which is involved in the field of genome editing. At ARRIGE, we believe that education and dissemination of reliable news on genome-editing for experts, but also for patients associations and the lay public is fundamental to allow for democratic debates in the context of the emergence of a technology that bears the potential to revolutionize many aspects of our societies. We would like to use the expertise of ARRIGE to develop/assist in developing public engagement projects.
  • Consequently, we envisage the creation of expert multidisciplinary groups to tackle all these issues with input from all over the world, with the idea of creating genuine expertise and a real task force.

Why joining ARRIGE?

To be part of this initiative and be able to contribute with ideas, materials, guidelines, recommendations, protocols suitable for each one of the potential uses of genome editing, taking into account the views of all stakeholders. We will also plan to regularly organize meetings to discuss and progress in all these topics, and to help you to organize events on these topics locally. Forthcoming meetings are already planned in Paris November 2019 and Vienna January 2020.

ARRIGE members will be subscribed to a new email list (different from this one) and we will create spaces and resources for the efficient and operative discussion of all working groups.

Initial Categories of ARRIGE Members:
Individual (50 Euros/year)
Institutional (300 Euros/year, both for private and public institutions)

Useful Links & Information:
ARRIGE website
ARRIGE bylaws in French
ARRIGE bylaws in English
ARRIGE Founding Board and Scientific Committee
ARRIGE article at The CRISPR Journal

ARRIGE Founding Board:
President: Lluís Montoliu (Spain) | Vice-President: Hervé Chneiweiss (France) | General Secretary: François Hirsch (France) | Deputy General Secretary: Christine Lemaitre (France) | Treasurer: Cyril Sarrauste de Menthière (France) | Deputy Treasurer: Jennifer Merchant (France)  | Legal Advisor: Marion Abecassis (France) | Board member: Bernard Baertschi (Switzerland)

ARRIGE Scientific Committee:
Janet Rossant (Canada), Matthew Porteus (USA), Stephen Ekker (USA), Lydia Teboul (UK), Bruce Whitelaw (UK), Tony Nolan (UK), Yann Herault (France), Gaetan Burgio (Australia), Jerome Amir Singh (Canada), Eleonore Pauwels (USA), Ayola Akim Adegnika (Gabon), Fabiana Arzuaga (Argentina), Mylène Botbol (Belgium), Pierre Jouannet (France), Amar Jesani (India), Josep Casacuberta (Spain), Martina Crispo (Uruguay) and Juraj Koppel (Slovakia)

Looking forward to receiving your requests for registration as members of ARRIGE.

With my best wishes and my appreciation for all your support,

Lluis Montoliu
ARRIGE Founding President, on behalf of the ARRIGE Founding Board

ARRIGE association launched: the Scientific Committee

The ARRIGE Scientific Committee has been created and their duties include:

  1. to provide a forum of experience and knowledge-sharing in the field of genome-editing
  2. to ensure the quality and scientific integrity of the studies and reports undertaken by the focus groups of the Association
  3. to be responsible for the quality and the scientific integrity of the ethical recommendations the Association may draft for users of genome-editing technology, national and international decision-makers and the civil society at large.

Members of the ARRIGE Scientific Committee:

Janet Rossant (Canada), Matthew Porteus (USA), Stephen Ekker (USA), Lydia Teboul (UK), Bruce Whitelaw (UK), Tony Nolan (UK), Yann Herault (France), Gaetan Burgio (Australia), Jerome Amir Singh (Canada), Eleonore Pauwels (USA), Ayola Akim Adegnika (Gabon), Fabiana Arzuaga (Argentina), Mylène Botbol (Belgium), Pierre Jouannet (France), Amar Jesani (India), Josep Casacuberta (Spain), Martina Crispo (Uruguay) and Juraj Koppel (Slovakia)

ARRIGE association launched: the Founding Board

The ARRIGE association was registered in France on 4 December 2018 with the name Association for Responsible Research and Innovation in Genome Editing (ARRIGE) as a non-for-profit association.

The official address of ARRIGE is at the Center for Interdisciplinary Research (CRI), 8 rue Charles V, 75005 Paris, France.

These are the ARRIGE bylaws (in French). A copy in English will be made available shortly.

The objectives of ARRIGE are:

    1. to promote a global governance of genome editing through a comprehensive setting for all stakeholders, including academics, researchers, clinicians, public institutions, private companies, patient organizations and other non-governmental organizations, regulators, citizens, communication media, governmental agencies and decision makers
    2. to push forward the scientific, ethical, social, legal and political reflection in the field of genome editing
    3. to foster the development of genome editing technologies within a safe and ethical framework for individuals and for our societies
    4. the dissemination of reliable information regarding genome-editing technology for experts (all fields included), politicians and citizens throughout the world.

The Founding Board of ARRIGE is formed by:

President: Lluís Montoliu (Spain)
Vice-President: Hervé Chneiweiss (France)
General Secretary: François Hirsch (France)
Deputy General Secretary: Christine Lemaitre (France)
Treasurer: Cyril Sarrauste de Menthière (France)
Deputy Treasurer: Jennifer Merchant (France)
Legal Advisor: Marion Abecassis (France)
Board member: Bernard Baertschi (Switzerland)

The ARRIGE initiative featured in Nature Biotechnology

Nature Biotechnology 36, 485 (2018). doi:10.1038/nbt0618-485

The ARRIGE initiative is featured in this News&Comment article by Eric Smalley in Nature Biotechnology. Indeed a big challenge the one we have ahead of us but an unavoidable one, if we believe in the responsible use of genome editing techniques and in the engagement of all stakeholders that are involved in the process. Hands to work!.

Unexpected mutations were expected and unrelated to CRISPR

Scheme illustrating the effect of spontaneous mutations and genetic drift responsible for the divergence of animal subcolonies bred independently (Figure from Montoliu and Whitelaw, Transgenic Research, 2018, online May 31).

Bruce Whitelaw (The Roslin Institute, Edinburgh, Scotland, UK) and I, we have just published a commentary in the scientific journal Transgenic Research discussing the case of the Nature Methods paper by Schaefer et al. 2017 who initially reported the identification of numerous off-target sites altered after a genome-editing experiment in vivo, in mice. This paper has recently been retracted by the journal (March 30). As indicated by the authors in this commentary: “The most plausible explanation for the vast majority of the reported unexpected mutations were the expected underlying genetic polymorphisms that normally accumulate in two different colonies of the same mouse strain which occur as a result of spontaneous mutations and genetic drift. Therefore, the reported mutations were most likely not related to CRISPR-Cas9 activity.

The ARRIGE initiative featured in The CRISPR Journal

The ARRIGE initiative described in an article published in the second issue of The CRISPR Journal

The ARRIGE initiative is receiving plenty of attention and generating a lot of interest from media and scientific journals. This is the case of The CRISPR Journal, which features a description of the birth of ARRIGE in its second issue. This article is open access. If you want to know more information about the ideas behind the foundation of ARRIGE, how they were shaped, how they developed and crystalized in the recent kick-off meeting in Paris, essentially aiming toward the responsible use of genome editing technologies, you can now simply read this publication.

 

The ARRIGE initiative presented from the ComunicaBiotec blog

Article by Lluis Montoliu at the blog of the association ComunicaBiotec on the launching and objectives of ARRIGE.

The ARRIGE initiative is being presented from various newspapers, journals, web sites and associations. One of the recent articles about ARRIGE, about its launching in Paris and its objectives, has been written (in Spanish) by Lluis Montoliu for the blog of ComunicaBiotec, a Spanish Association of Communication in Biotechnology. In this article, Lluis Montoliu describes the scenario where ARRIGE was born, the precedent activities and the future ahead, trying to promote the responsible use of genome editing technologies.

 

ARRIGE coverage from Germany

Article in German published by the internet newspaper Pflanzenforschung.de reporting about the ARRIGE kick-off meeting and the overall initiative.

The Online Journal Pflanzenforschung.de just published an article introducing the ARRIGE initiative and the kick-off meeting held in Paris on March 23, 2018. This article is entitled “Welcome ARRIGE!
Vereinigung zum verantwortlichen Umgang mit Genome Editing gegründet” and is written in German.

ARRIGE coverage from Spain

Article about the ARRIGE kick-off meeting published by the Spanish newspaper DIARIO MEDICO

The Spanish newspaper DIARIO MEDICO, specialized in the field of health and regularly read by many professional colleagues including those from Hospitals, Clinics and Biomedical research centres in Spain, covered the launching of the ARRIGE and our kick-off meeting in a recent article, written by José A. Plaza and published on April 8, 2018. The article is in Spanish and is entitled: “Toward an international governance in CRISPR“.

ARRIGE Kick-Off meeting: Lluis Montoliu workshop conclusion and next steps


Final comments, workshop conclusion and next steps by Lluis Montoliu (CNB-CSIC and CIBERER-ISCIII, Madrid, Spain) at the ARRIGE Kick-Off meeting. ARRIGE Kick-Off meeting was held on 23 March 2018 at the Région Île-de-France Parliament, in Paris, France.

ARRIGE Kick-Off meeting video files available from the new ARRIGE YouTube channel. All 21 video files can be played and watched in the correct order through the ARRIGE Kick-Off meeting YouTube Play List.

More information about ARRIGE can be obtained from the ARRIGE web site.

ARRIGE Kick-Off meeting: Magnus Magnusson final comments from UNESCO


Final comments from Magnus Magnusson (Director of Partnership and Outreach, SHSS, UNESCO) at the ARRIGE Kick-Off meeting. ARRIGE Kick-Off meeting was held on 23 March 2018 at the Région Île-de-France Parliament, in Paris, France.

ARRIGE Kick-Off meeting video files available from the new ARRIGE YouTube channel. All 21 video files can be played and watched in the correct order through the ARRIGE Kick-Off meeting YouTube Play List.

More information about ARRIGE can be obtained from the ARRIGE web site.

ARRIGE Kick-Off meeting: Lauren Roberts & Louise James on involving patients

Presentation by Lauren Roberts and Louise James (Genetic Alliance UK) on involving patients in the discussion of issues raised by genome editing technology at the ARRIGE Kick-Off meeting. ARRIGE Kick-Off meeting was held on 23 March 2018 at the Région Île-de-France Parliament, in Paris, France.

ARRIGE Kick-Off meeting video files available from the new ARRIGE YouTube channel. All 21 video files can be played and watched in the correct order through the ARRIGE Kick-Off meeting YouTube Play List.

More information about ARRIGE can be obtained from the ARRIGE web site.

ARRIGE Kick-Off meeting: Béatrice Holtz on IP & economic issues raised by GE technology

Presentation by Béatrice Holtz (LAVOIX, Paris, France) on the Intellectual properties and economic issues raised by genome editing technology at the ARRIGE Kick-Off meeting. ARRIGE Kick-Off meeting was held on 23 March 2018 at the Région Île-de-France Parliament, in Paris, France.

ARRIGE Kick-Off meeting video files available from the new ARRIGE YouTube channel. All 21 video files can be played and watched in the correct order through the ARRIGE Kick-Off meeting YouTube Play List.

More information about ARRIGE can be obtained from the ARRIGE web site.

ARRIGE Kick-Off meeting: Filipa Ferraz de Oliveira on Animal issues raised by GE technology

Presentation by Filipa Ferraz de Oliveira (European Research Council, Ethics sector, Brussels, Belgium) on the Animal issues raised by genome editing technology at the ARRIGE Kick-Off meeting. ARRIGE Kick-Off meeting was held on 23 March 2018 at the Région Île-de-France Parliament, in Paris, France.

ARRIGE Kick-Off meeting video files available from the new ARRIGE YouTube channel. All 21 video files can be played and watched in the correct order through the ARRIGE Kick-Off meeting YouTube Play List.

More information about ARRIGE can be obtained from the ARRIGE web site.

ARRIGE Kick-Off meeting: Andreas Kurtz on Environmental issues raised by GE technology

Presentation by Andreas Kurtz (Charité Hospital, Berlin, Germany and European Group of Ethics, EGE) at the ARRIGE Kick-Off meeting on the Environmental issues raised by genome editing technology. ARRIGE Kick-Off meeting was held on 23 March 2018 at the Région Île-de-France Parliament, in Paris, France.

ARRIGE Kick-Off meeting video files available from the new ARRIGE YouTube channel. All 21 video files can be played and watched in the correct order through the ARRIGE Kick-Off meeting YouTube Play List.

More information about ARRIGE can be obtained from the ARRIGE web site.

ARRIGE Kick-Off meeting: Peter Mills on Human issues raised by GE technology

Presentation by Peter Mills (Nuffield Council on Bioethics, London, UK) on Human issues raised by genome editing technology at the ARRIGE Kick-Off meeting. ARRIGE Kick-Off meeting was held on 23 March 2018 at the Région Île-de-France Parliament, in Paris, France.

ARRIGE Kick-Off meeting video files available from the new ARRIGE YouTube channel. All 21 video files can be played and watched in the correct order through the ARRIGE Kick-Off meeting YouTube Play List.

More information about ARRIGE can be obtained from the ARRIGE web site.

ARRIGE Kick-Off meeting: Hervé Chneiweiss on presentation of ARRIGE


Talk by Hervé Chneiweiss (INSERM Ethics Committee) on the Ethics of the genome editing technologies: presentation of ARRIGE, at the ARRIGE Kick-Off meeting. ARRIGE Kick-Off meeting was held on 23 March 2018 at the Région Île-de-France Parliament, in Paris, France.

ARRIGE Kick-Off meeting video files available from the new ARRIGE YouTube channel. All 21 video files can be played and watched in the correct order through the ARRIGE Kick-Off meeting YouTube Play List.

More information about ARRIGE can be obtained from the ARRIGE web site.

ARRIGE Kick-Off meeting: Mylène Botbol-Baum on anthropological and societal impact


Presentation by Mylène Botbol-Baum (INSERM Ethics Committee and Catholic University of Louvain, Brussels, Belgium) on “Taking seriously the anthropological and societal impact of genome editing technologies” at the ARRIGE Kick-Off meeting. ARRIGE Kick-Off meeting was held on 23 March 2018 at the Région Île-de-France Parliament, in Paris, France.

ARRIGE Kick-Off meeting video files available from the new ARRIGE YouTube channel. All 21 video files can be played and watched in the correct order through the ARRIGE Kick-Off meeting YouTube Play List.

More information about ARRIGE can be obtained from the ARRIGE web site.

ARRIGE Kick-Off meeting: review of ethics positions by Ewa Bartnik


Review of ethics positions, reports, documents published on gene editing by other groups and institutions, presented by Ewa Bartnik (University of Warsaw, Poland), former rapporteur UNESCO IBC. ARRIGE Kick-Off meeting was held on 23 March 2018 at the Région Île-de-France Parliament, in Paris, France.

ARRIGE Kick-Off meeting video files available from the new ARRIGE YouTube channel. All 21 video files can be played and watched in the correct order through the ARRIGE Kick-Off meeting YouTube Play List.

More information about ARRIGE can be obtained from the ARRIGE web site.

ARRIGE Kick-Off meeting: keynote lecture by Francisco J.M. Mojica


Keynote Lecture delivered by Francisco J.M. Mojica (University of Alicante, Spain) on “Setting the stage, where do we stand today with CRISPR technology” and introduced by Lluis Montoliu (CNB-CSIC and CIBERER-ISCIII, Madrid, Spain). ARRIGE Kick-Off meeting was held on 23 March 2018 at the Région Île-de-France Parliament, in Paris, France.

ARRIGE Kick-Off meeting video files available from the new ARRIGE YouTube channel. All 21 video files can be played and watched in the correct order through the ARRIGE Kick-Off meeting YouTube Play List.

More information about ARRIGE can be obtained from the ARRIGE web site.